Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.

By D. Tillett, E. Dittmann, M. Erhard, H. Döhren, Thomas Börner, B. Neilan. Chemistry and Biology, 2000

956 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0404922c0bc2b0066a5c419c692cadecedaae7d1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Simultaneous changes in cell quotas of microcystin, chlorophyll a, protein and carbohydrate during different growth phases of a batch culture experiment with Microcystis aeruginosa (2004, background): “Microcystin is known to be synthesized by a complex multienzyme-linked modular system involving domains of polyketide synthetase and non-ribosomal peptide synthetase (Nishizawa et al., 1999; Kaebernick et al., 2000, 2002; Tillett et al., 2000).”
The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity (2012, background): “Although the biochemical function of these domains has not been experimentally defined, they appear to be involved in the modification of the incorporated amino acid, for example the dehydration of serine to dehydroalanine [57,58].”
The effects of temperature and nutrients on the growth and dynamics of toxic and non-toxic strains of Microcystis during cyanobacteria blooms (2009, background): “Harmful cyanobacteria such as Microcystis have been found to have an optimal temperature for growth and photosynthesis at, or above, 25 8 C( Konopka and Brock, 1978; Takamura et al., 1985; Robarts and Zohary, 1987; Reynolds, 2006; Jo ¨ hnk et al., 2008; Paerl and Huisman, 2008).”
Cyanobacterial peptides - nature's own combinatorial biosynthesis. (2006, methodology): “All rights reserved Downloaded from https://academic.oup.com/femsre/article-abstract/30/4/530/2367432 by guest on 29 July 2018 during biosynthesis (Tillett et al., 2000).”
Deciphering the effects of nitrogen, phosphorus, and temperature on cyanobacterial bloom intensification, diversity, and toxicity in western Lake Erie (2019, background): “The mcyE gene was chosen as it is one of several microcystin synthetase genes and encodes an aminotransferase that plays a key role in the production of microcystin (Tillett et al. 2000).”
Toxic cyanobacteria: the evolving molecular toolbox (2003, background): “tive microcystin transporter protein (Tillett et al. 2000), supports the idea that microcystin might function in sensing (Dittmann et al.”
A PCR‐BASED TEST TO ASSESS THE POTENTIAL FOR MICROCYSTIN OCCURRENCE IN CHANNEL CATFISH PRODUCTION PONDS 1,2 (2002, methodology): “Several methods for the assessment of microcystin are available (Chorus and Bartram 1999), including HPLC, MS, ELISA, or direct DNA tests to detect genetic sequences unique for the multigene cluster required for toxin synthesis (Tillett et al. 2000, Nishizawa et al. 2000).”
Diversity and dynamics of microcystin―Producing cyanobacteria in China's third largest lake, Lake Taihu (2009, background): “It is known that MCs are synthesized nonribosomally by an integrated peptide-polyketide synthetase system encoded by the microcystin synthetase (mcy) gene cluster (Dittmann et al., 1997; Nishizawa et al., 1999, 2000; Tillett et al., 2000).”
Sustainability and cyanobacteria (blue-green algae): facts and challenges (2011, background): “They are relatively small (MW 800–1,100 Da) in comparison to other cell oligopeptides and polypeptides, and are synthesised nonribosomally by a peptide synthetase (Tillett et al. 2000; Kaebernick et al. 2002).”
Microcystis genotype succession in relation to microcystin concentrations in freshwater lakes (2007, background): “Whether or not a genotype can produce microcystins depends on the presence of intact genes from the microcystin synthetase gene complex (Dittmann et al. 1997, Tillett et al. 2000, Kurmayer et al. 2002).”
Effects of nitrogenous compounds and phosphorus on the growth of toxic and non-toxic strains of Microcystis during cyanobacterial blooms (2010, background): “Beyond this N in the toxin, toxic Microcystis strains will have additional N requirements associated with the enzymes involved in the synthesis of microcystin (Tillett et al. 2000), as well as with additional light-harvesting pigments they may possess (Hesse et al. 2001).”
The Genetic Basis of Toxin Production in Cyanobacteria (2009, background): “Each module of the multifunctional peptide synthetase contains specific functional domains for activation (aminoacyl adenylation domain) and thioesterification (peptide carrier domain) of the amino acid substrate and for the elongation (condensation domain) of the growing peptide (Tillett et al., 20”