DAMP-sensing receptors in sterile inflammation and inflammatory diseases

By Tao Gong, Lei Liu, Wei Jiang, Rongbin Zhou. Nature reviews. Immunology, 2019

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How researchers see this paper

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Mitochondrial DNA in inflammation and immunity (2020, neutral): “Additionally, damage-associated molecular patterns (DAMPs) are immune triggers that arise from the cell itself, such as proteins or DNA, and can activate innate immune pathways [2].”
Pattern recognition receptors in health and diseases (2021, background): “However, the host will produce some proteins and metabolites after being stimulated by its own tissue damage, cell necrosis, and other factors.(30) These molecules are called damage-associated molecular pattern (DAMP).”
Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity (2020, background): “healthy tissue express many of the receptors to PAMPs and DAMPs known to trigger innate immune responses [90] (Figure 3), in particular TLRs, including TLR4 [90], which is sometimes erroneously attributed only to microglia.”
The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “, Heat shock proteins), whereas PAMPS are present on infectious pathogens (Gong et al., 2020).”
Cellular and molecular mechanisms of skin wound healing (2024, neutral): “70).”