Mechanism-based concepts of size and maturity in pharmacokinetics.

By B. Anderson, N. Holford. Annual Review of Pharmacology and Toxicology, 2008

1,096 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Pharmacology, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/03d334a605a96e00b619f50d96aa977a531c7230

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In Pharmacology

1. Amin Rostami-Hodjegan
2. Masoud Jamei
3. G. Dickinson

Citations in the corpus

• A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates. (2009, background): “Although body size may be the most important determinant of pharmacokinetics after maturation of elimination routes, 124) it would be naive to assume that variable maturation rates of different elimination routes 115,125,126) and other factors such as age-related protein binding 127) can be…”