Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

By Anand Kumar, D. Roberts, Kenneth E. Wood, B. Light, J. Parrillo, S. Sharma, R. Suppes, D. Feinstein, S. Zanotti, Leo Taiberg and 3 more. 2006

5,782 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Surgery

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Katherine A. Heller
2. Joseph D. Futoma
3. Sanjay Hariharan
4. A. Rhodes
5. Laura Evans
6. Suchi Saria
7. M. Cecconi
8. Janice L. Zimmerman

In Surgery

1. Katherine A. Heller
2. Joseph D. Futoma
3. Sanjay Hariharan
4. Suchi Saria
5. Mohammed Saeed
6. F. Tenover

Citations in the corpus

• Sepsis biomarkers: a review (2010, neutral): “and specific treatment [5,6].”
• An Improved Multi-Output Gaussian Process RNN with Real-Time Validation for Early Sepsis Detection (2017, background): “prove outcomes (Ferrer et al. (2009)). Early intervention is crucial, as every hour that treatment is delayed after the onset of hypotension increases the risk of mortality from septic shock by 7.6% (Kumar et al. (2006)). Additionally, recent work found timely administration of a 3-hour care bundle ”
• Benchmarking the Incidence and Mortality of Severe Sepsis in the United States* (2013, background): “It is also likely that clinical advances including early goal-directed therapy and prioritization of early, appropriate antimicrobials (25, 26), in addition to highly publicized mortality reduction campaigns, play a role (27).”
• The Timing of Early Antibiotics and Hospital Mortality in Sepsis (2017, background): “While no one recommends delaying antibiotics for sepsis patients, the existing evidence supporting the mortality benefits of earlier antibiotic administration is mixed.(14-30, 32) In a frequently cited study, Kumar and others retrospectively evaluated 2,154 critically ill patients with septic shock ”
• Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour: Results From a Guideline-Based Performance Improvement Program* (2014, background): “In addition, Kumar et al (5) reported that delays in administration of antibiotics are common: 79% of patients did not receive antibiotics until the onset of hypotension, and of those patients, only 14.”