Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour: Results From a Guideline-Based Performance Improvement Program*
By R. Ferrer, I. Martín-Loeches, G. Phillips, Tiffany M. Osborn, S. Townsend, R. Dellinger, A. Artigas, C. Schorr, Mitchell M. Levy. Critical Care Medicine, 2014
1,360 citations recorded by the source corpus.
Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/9da72cbbae464f3ce6387e75b354761b2419fb54
How researchers see this paper
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In Critical Care and Intensive Care Medicine
In Epidemiology
- A. Rhodes
- Laura Evans
- M. Cecconi
- Janice L. Zimmerman
- Mitchell M. Levy
- R. Dellinger
- Mervyn Singer
- Djillali Annane
Citations in the corpus
- The Timing of Early Antibiotics and Hospital Mortality in Sepsis (2017, background): “While no one recommends delaying antibiotics for sepsis patients, the existing evidence supporting the mortality benefits of earlier antibiotic administration is mixed.(14-30, 32) In a frequently cited study, Kumar and others retrospectively evaluated 2,154 critically ill patients with septic shock ”
- Sepsis and septic shock. (2018, background): “64 The evidence around timing, however, is not backed by trial data, and some controversy still exists.”
- Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “Despite a meta-analysis of mostly poorquality studies that failed to demonstrate a benefit of rapid antimicrobial therapy, the largest and highest-quality studies support giving appropriate antimicrobials as soon as possible in patients with sepsis with or without septic shock [57, 74, 79-81].”