Role for the p53 homologue p73 in E2F-1-induced apoptosis

By M. Irwin, M. Marin, A. Phillips, Ratnam S. Seelan, David I. Smith, Wanguo Liu, E. Flores, K. Tsai, T. Jacks, Karen H. Vousden and 1 more. Nature, 2000

694 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/035724c92a0ec13cc3430eff8786c4d52d1c0b32

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Scott W. Lowe
2. Karen H. Vousden

In Molecular Biology

1. Scott W. Lowe
2. J. Fridman
3. K. Helin
4. Karen H. Vousden
5. E. L. Denchi
6. J. Simon
7. J. Campisi
8. Guido Kroemer

In Oncology

1. Scott W. Lowe
2. J. Fridman
3. K. Helin
4. Karen H. Vousden
5. J. Campisi
6. Guido Kroemer
7. Arnold J. Levine
8. W. Gu

Citations in the corpus

• The E2F transcriptional network: old acquaintances with new faces (2005, background): “In cells lacking p53, the p53 family member, p73, has been shown to play a role in E2F-induced cell death (Irwin et al., 2000; Lissy et al., 2000; Stiewe and Putzer, 2000).”
• The E2F family: specific functions and overlapping interests (2004, background): “Among these are ARF, p73, APAF1, Casp3, Casp7 and several members of the BH3-only family (Irwin et al, 2000; Stiewe and Putzer, 2000; Moroni et al, 2001; Müller et al, 2001; Nahle et al, 2002).”
• p73: Friend or foe in tumorigenesis (2002, background): “E2F1 regulates p73 levels directly, by binding to E2F-binding sites within the TAp73 promote”
• Control of apoptosis by p53 (2003, background): “For example, E2F-1 (which activates p53 to promote apoptosis) can induce p73, leading to apoptosis in p53null cells (Irwin et al., 2000; Lissy et al., 2000; Stiewe and Putzer, 2000).”
• Regulation and mechanisms of mammalian double-strand break repair (2003, background): “It is also known that ATM directly phosphorylates the transcription factor E2F1, which results in increased P73 (a P53 analog) expression and apoptosis in the absence of P53 (Irwin et al., 2000; Lin et al., 2001).”