Invariant Chain Induces B Cell Maturation by Activating a TAFII105-NF-κB-dependent Transcription Program*
By D. Matza, O. Wolstein, R. Dikstein, I. Shachar. Journal of Biological Chemistry, 2001
111 citations recorded by the source corpus.
Early stages of B cell development occur in the bone marrow, resulting in formation of immature B cells. From there these immature cells migrate to the spleen where they differentiate to mature cells. This final maturation step is crucial for the B cells to become responsive to antigens and to participate in the immune response. Recently, invariant chain (Ii), a major histocompatibility complex class II chaperone, as well as the transcription factors c-Rel and p65/RelA, were found to play a role in the final antigen-independent differentiation stage of B cells in the spleen. In this study, we investigated a possible link between Ii-dependent B cell maturation and the NF-κB pathway. Our studies indicate that Ii-induced B cell maturation involves activation of transcription mediated by the NF-κB p65/RelA homodimer and requires the B cell-enriched coactivator TBP-associated factorII105.
Subfields: Cancer Research, Immunology
View Paper: https://www.semanticscholar.org/paper/032b1590fa87683c067c6b43b6d824f1fed46523
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Citations in the corpus
- MIF Signal Transduction Initiated by Binding to CD74 (2003, background): “Thus, the MIF binding activity of CD74 provides insight into the biology of CD74 outside of its role in the transport of class II, and supports those papers that have defined an accessory signaling function for CD74 in immune cell physiology (57, 58, 61).”
- CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “CD74 has been shown to undergo regulated intramembrane cleavage in B lymphocytes, leading to the activation of transcription by the p65-RelA homodimer (Matza et al., 2001, 2002; Starlets et al., 2006).”