The structure and function of SMC and kleisin complexes.

By Kim Nasmyth, C. Haering. Annual Review of Biochemistry, 2005

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Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells. (2011, background): “The protein complexes Structural Maintenance of Chromosomes (SMCs) and their kleisin subunits also play important central roles in sister chromatid separation at anaphase (47).”
Cohesin: its roles and mechanisms. (2009, background): “proteins that regulate cohesin’s association with chromosomes or establishment or release of cohesion (59, 120, 127, 131)”
PCNA, the maestro of the replication fork. (2007, neutral): “This physical coupling, known as cohesion, is mediated by a proteinaceous ring, termed cohesin, which is composed of the four subunits Smc1, Smc3, Scc1, and Scc3 (Nasmyth and Haering, 2005).”
The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “…proteins are conserved among members of all three kingdoms, suggesting that they are the most conserved of all architectural proteins and that they were responsible for chromosome organization long before other, sometimes more specialized, proteins emerged (Nasmyth and Haering, 2005; Hirano, 2006).”
Enhancer function: new insights into the regulation of tissue-specific gene expression (2011, neutral): “Cohesins are known to mediate sister chromatid cohesion, which is necessary for proper chromosome segregation and DNA repai”