Human skin Langerhans cells are targets of dengue virus infection

By Shuenn-Jue Wu, G. Grouard-Vogel, Wellington Sun, J. Mascola, E. Brachtel, R. Putvatana, M. Louder, L. Filgueira, M. Marovich, H. Wong and 7 more. Nature Medicine, 2000

713 citations recorded by the source corpus.

Subfields: Immunology, Public Health, Environmental and Occupational Health, Virology

View Paper: https://www.semanticscholar.org/paper/02c25355235158ccfe3e8460d265c85df4407d08

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In Immunology

1. R. Steinman
2. Jacques Banchereau
3. K. Palucka

Citations in the corpus

• Dengue Virus Pathogenesis: an Integrated View (2009, background): “During the feeding of mosquitoes on humans, DENV is presumably injected into the bloodstream, with spillover in the epidermis and dermis, resulting in infection of immature Langerhans cells (epidermal dendritic cells [DC]) (136, 263), and keratinocytes (136).”
• DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells (2003, result): “2 D, bottom), which is consistent with prior EM observations that replicating DV (at 24–48 h) is found in the endoplasmic reticulum of DCs (9, 12).”
• Dengue: a continuing global threat (2010, background): “Host factors that increase the risk of severe dengue disease include female sex, several human leukocyte antigen (HLA) class I alleles, a promoter variant of the DC-SIGN receptor gene, a single-nucleotide polymorphism in the tumour necrosis factor (TNF) gene and AB blood group 31–36 .”