Qinghaosu (Artemisinin): The Price of Success

By N. J. White. Science, 2008

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Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment (2010, background): “They are at the top of the list of new antimalarial drugs in terms of efficacy, low toxicity, resistance, cost, rapidity of action and first order pharmacokinetics (White 2008; Krishna et al. 2008).”
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination (2011, neutral): “reductions in parasitemia (3, 363, 509), and treatment with TABLE 2.”
Introduction to the Different Classes of Natural Products (2009, background): “, alkylation of biological macromolecules or the production of reactive oxygen species are discussed as well (White, 2008) .”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, background): “of derivatives, such as sodium artensunate or artemether, that are nowadays widely used to treat malaria (Klayman, 1985; White, 2008).”
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin (2012, background): “Chemical synthesis of artemisinin is not economically feasible because of the complexity and low yield of the process (7), however semisynthesis of artemisinin following microbial production of a precursor molecule may be feasible (6).”