Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation.

By I. del Conde, C. Shrimpton, P. Thiagarajan, José A. López. Blood, 2005

1,067 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/029a738fb46f91f07d2bc3bd67e64241dd55ae3d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Richard J. Simpson
2. Suresh Mathivanan
3. M. Levi
4. W. Stoorvogel

In Molecular Biology

1. Suresh Mathivanan
2. Richard J. Simpson
3. H. Ji
4. A. Llorente
5. Jan Lötvall
6. P. Vader
7. M. Wood
8. María Yáñez-Mó

Citations in the corpus

• Inflammation, endothelium, and coagulation in sepsis (2008, background): “As described above, platelets also interact with monocyte-derived MPs in a P-selectin-dependent manner and by this means enhance TF expression on MPs [36, 37].”
• Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “It is increasingly evident that EVs play a major role in the regulation of physiological processes, such as tissue repair (4), stem cell maintenance (5), and coagulation (6).”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “Monocyte-derived TF EVs were reported to bind activated P-selectin-expressing platelets via PSGL-1 and to fuse with them, leading to enhanced TF-FVIIa activity (236).”
• Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1 (2013, background): “whether exosomes enter cells through direct fusion with the plasma membrane of recipient cells or through endocytosis (18, 19).”
• Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, neutral): “, GPIb, GPIIb–IIIa and P-selectin [32–35], and integrins, e.”
• Microvesicles: mediators of extracellular communication during cancer progression (2010, background): “…hypothesized to have a role in the initial ‘pinching’ events, because the microvesicles released from activated neutrophils contained high levels of cholesterol and pharmacological depletion of cellular cholesterol inhibits microvesicle shedding (Del Conde et al., 2005; Pilzer et al., 2005).”