Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
By G. Arpino, V. Bardou, G. Clark, R. Elledge. Breast Cancer Research, 2004
859 citations recorded by the source corpus.
IntroductionInvasive lobular carcinoma (ILC) comprises approximately 10% of breast cancers and appears to have a distinct biology. Because it is less common than infiltrating ductal carcinoma (IDC), few data have been reported that address the biologic features of ILC in the context of their clinical outcome. In the present study we undertook an extensive comparison of ILC and IDC using a large database to provide a more complete and reliable assessment of their biologic phenotypes and clinical behaviors.MethodsThe clinical and biological features of 4140 patients with ILC were compared with those of 45,169 patients with IDC (not otherwise specified). The median follow-up period was 87 months.ResultsIn comparison with IDC, ILC was significantly more likely to occur in older patients, to be larger in size, to be estrogen and progesterone receptor positive, to have lower S-phase fraction, to be diploid, and to be HER-2, p53, and epidermal growth factor receptor negative. It was more common for ILC than for IDC to metastasize to the gastrointestinal tract and ovary. The incidence of contralateral breast cancer was higher for ILC patients than for IDC patients (20.9% versus 11.2%; P < 0.0001). Breast preservation was modestly less frequent in ILC patients than in IDC patients. The 5-year disease-free survival was 85.7% for ILC and 83.5% for IDC (P = 0.13). The 5-year overall survival was 85.6% for ILC and 84.1% for IDC (P = 0.64).ConclusionDespite the fact that the biologic phenotype of ILC is quite favorable, these patients do not have better clinical outcomes than do patients with IDC. At present, management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology.
Subfields: Cancer Research, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/02972e170b6d42dad7b6cff348d65f6dd4f552f4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Matthew Meyerson
- Gad Getz
- M. Lawrence
- Christopher Sander
- Peter W. Laird
- Charles M. Perou
- Andrew H. Beck
- Elaine R. Mardis
In Pathology and Forensic Medicine
Citations in the corpus
- Comprehensive molecular portraits of invasive lobular breast cancer (2015, background): “Importantly, ILC infiltrative growth pattern complicates both physical exam andmammographic findings and its patterns of metastatic spread often differ from those of IDC (Arpino et al., 2004).”
- Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. (2006, background): “While metastasis to lung, liver, and bone marrow is common in most types of human breast cancer, including ILC, gastrointestinal and peritoneal metastases are more frequent in ILC (Arpino et al., 2004).”
- Awareness and current knowledge of breast cancer (2017, background): “ILC originates in the milk glands (lobules) of the breast, but frequently extends to other areas of the body [44].”