Interactions between the microbiota and pathogenic bacteria in the gut
By A. Bäumler, V. Sperandio. Nature, 2016
1,235 citations recorded by the source corpus.
The microbiome has an important role in human health. Changes in the microbiota can confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound impact on the microbiota that alters the nutritional landscape of the gut and can lead to the expansion of pathogenic populations. Pathogenic bacteria exploit microbiota-derived sources of carbon and nitrogen as nutrients and regulatory signals to promote their own growth and virulence. By eliciting inflammation, these bacteria alter the intestinal environment and use unique systems for respiration and metal acquisition to drive their expansion. Unravelling the interactions between the microbiota, the host and pathogenic bacteria will produce strategies for manipulating the microbiota against infectious diseases.
Subfields: Food Science, Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/027ccf1bad63261173f7268417f989d2278d3a00
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Citations in the corpus
- The gut microbiota and inflammatory bowel disease (2014, positive): “Currently, there is a lack of knowledge about how exactly these interactions occur and, therefore, about how the gut microbiota is collectively associated with health and disease.(29,30) Based on the findings of Chapter 2, Chapter 3 moves beyond the discovery of independent altered microbial abundan”
- The microbiota of the respiratory tract: gatekeeper to respiratory health (2017, background): “In addition to this symbiotic relationship, the respiratory microbiota probably has a role in the structural maturation of the respiratory tract 5 and in shaping local immunity 6,7 .”
- Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development (2020, background): “Under normal conditions, gut microbiota offer many benefits to the host, such as harvesting energy [4], protecting against pathogens [5], and regulating host immunity [6].”