p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

By Kevin C. Wang, Jieun A. Kim, Rajeev Sivasankaran, R. Segal, Zhigang He. Nature, 2002

832 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/0230f7f63435f47f241383396cb700641b0da8c4

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In Cellular and Molecular Neuroscience

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2. M. Chao
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4. B. Lu

In Developmental Neuroscience

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Citations in the corpus

• Neurotrophin-regulated signalling pathways (2006, background): “…signaltransmitting subunit of the Nogo receptor complex (NogoR, Lingo, p75NTR) that mediates inhibitory effects on axon growth of three myelin-associated glycoproteins—Nogo, myelin-associated glycoprotein and oligodendrocyte-myelin glycoprotein (Wang et al. 2002; Wong et al. 2002; Mi et al. 2004).”
• Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation (2006, background): “Two of the important coreceptors mediating the inhibitory mechanisms of myelin components on growing axons, the neurotrophin receptor p75 NTR (Wang et al., 2002; Wong et al., 2002) as well as LINGO (Mi et al., 2004), are present on OPCs (Dowling et al., 1999; Chang et al., 2000; Petratos et al.,…”
• The role of the Rho GTPases in neuronal development. (2005, background): “Primary neurons from p75NTR knockout mice are no longer responsive to CNS myelin, Nogo-66, OMgp, and MAG (Wang et al. 2002a; Yamashita et al. 2002), and an antibody against p75NTR abolishes MAG-induced repulsive turning of Xenopus axonal growth cones and calcium elevation (S.T. Wong et al. 2002).”
• Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “The absence of a cytoplasmic domain in the structure of the Nogo receptor implies that other components are involved in signalling, and association of the Nogo receptor with the p75 receptor has proved to be a surprising and intriguing solution to this proble”