Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.

By L. Glantz, D. Lewis. Archives of General Psychiatry, 2000

1,645 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/01f3f4a103f6c1ed7293df5e73e5d5dfab711fa5

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In Cellular and Molecular Neuroscience

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Citations in the corpus

The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, neutral): “Glantz and Lewis(173) observed that pyramidal cells located in layer III of the DLPFC of subjects with schizophrenia exhibited a 23% reduction in spine density when compared with normal controls suggesting a decrease in excitatory inputs to these cells.(173) Table 5.”
Schizophrenia risk from complex variation of complement component 4 (2016, background): “The most strongly associated markers in several large case/ control cohorts were near a complex, multi-allelic, and only partially characterized form of genome variation that affects the C4 gene encoding complement component 4 (Extended Data Fig.”
Sex differences in brain maturation during childhood and adolescence. (2001, background): “Cerebral Cortex Jun 2001, V 11 N 6 555 studies (Glantz and Lewis, 2000).”
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1 (2010, background): “Neuropathological studies with autopsied brains from individuals with schizophrenia have reported reduced numbers of dendritic spine”
ERP Repetition Effects and Mismatch Negativity Generation A Predictive Coding Perspective (2007, background): “…have direct implications for MMN generation and predictive coding models: (1) the loss of dendritic spines in supragranular layer (II/III) pyramidal neurons (Garey et al., 1998; Glantz & Lewis, 2000) and (2) functional impairment of cortical inhibitory interneurons (Lewis, Hashimoto, & Volk, 2005).”
Adolescence as a neurobiological critical period for the development of higher-order cognition (2018, neutral): “, 2015) and pruning of synapses (Glantz and Lewis, 2000) in the PFC (Faludi and Mirnics, 2011).”
Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses (2011, background): “A decrease in the density of dendritic spines in regions of the cerebral cortex has been linked to schizophrenia (Blanpied and Ehlers, 2004; Garey et al., 1998; Glantz and Lewis, 2000).”
The Computational Anatomy of Psychosis (2013, background): “, 2001), and these neurons have smaller basal dendrites (Glantz and Lewis, 2000; Kalus et al., 2000) and lower dendritic spine density (Kolluri et al.”
Structure and function of dendritic spines. (2002, result): “The other study (144) showed a 21% decrease in spine density in schizophrenic patients compared with age-matched controls.”
Schizophrenia as a disorder of developmentally reduced synaptic connectivity. (2000, result): “This triggered the first suggestion that schizophrenia was a disorder of neuritic pruning,(17) a suggestion supported by subsequent postmortem histopathologic studies demonstrating reduced spine densities and smaller dendritic arbors on the pyramidal cells of the prefrontal cortex in schizophrenia.(”