Rational design of cationic lipids for siRNA delivery

By S. Semple, Akin Akinc, Jianxin Chen, Ammen P Sandhu, B. Mui, C. Cho, D. Sah, D. Stebbing, Erin J. Crosley, Ed Yaworski and 31 more. Nature Biotechnology, 2010

1,657 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/01dd59da6cc85d70e43477b3d81f41146264e960

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Juliano
2. O. Farokhzad
3. N. Bertrand
4. Xiaoyang Xu
5. P. McCray
6. B. Davidson

In Molecular Biology

1. N. Bertrand
2. Xiaoyang Xu
3. P. McCray
4. O. Farokhzad
5. M. Hope
6. R. Juliano
7. A. Kabanov
8. Xueqing Zhang

Citations in the corpus

• Nonviral delivery of self-amplifying RNA vaccines (2012, background): “Recently, there has been an exponential growth in the development of clinically suitable nonviral delivery systems for siRNA (19, 20); we have taken advantage of these innovations to develop the LNP/RNA formulation and have now embarked on a more extensive evaluation of other nonviral delivery syste”
• Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. (2019, neutral): “19,20 Although the mechanism of mRNA delivery by the LNPs is not fully understood, it is generally accepted that these multicomponent LNPs are taken up by endocytosis and can electrostatically attach and fuse with the cell membrane using inverted non-bilayer lipid phases.”
• Brief update on endocytosis of nanomedicines (2019, background): “Lipids and polymers exhibiting low pKa and high endosomal buffering capacity have been routinely correlated with high transfection efficacy [7,110,310,312,313,317].”
• Lipid Nanoparticle Systems for Enabling Gene Therapies. (2017, background): “Evolution of Ionizable Cationic Lipids DODAP, originally used for encapsulating antisense oligonucleotides,(10) was replaced by DLinDMA in LNP siRNA systems to enhance potency.(16) Subsequently DLinKC2DMA was found to further enhance potency,(13) leading to a large synthesis effort to arrive at the ”
• Nanocarriers for drug delivery applications (2018, neutral): “2016; Semple 2010; Tam et al.”