Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3

By Taija Mäkinen, Tanja Veikkola, S. Mustjoki, Terhi Karpanen, B. Catimel, E. Nice, Lyn M. Wise, A. Mercer, H. Kowalski, D. Kerjaschki and 3 more. EMBO Journal, 2001

874 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/01c98ba2e8175bc1a707f1fc5c7a2acafc030a78

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. B. Olsen
2. Kai Hu
3. A. V. van Oosterom
4. L. Claesson‐Welsh
5. A. Hoeben
6. E. D. de Bruijn
7. M. Highley
8. S. Koch

In Oncology

1. B. Olsen
2. Kai Hu
3. L. Claesson‐Welsh

Citations in the corpus

• Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. (2018, background): “remodeling and extension, reorganizing themselves into a functional network of lymphatic vessels [3, 61].”
• Signal transduction by vascular endothelial growth factor receptors. (2012, background): “Another important pathway downstream of VEGFC/VEGFR3 is the PI3K/AKT pathway (Makinen et al. 2001), which may be critical in lymphendothelial cell migration.”
• The roles of vascular endothelial growth factor in bone repair and regeneration (2016, background): “VEGFR3 mainly binds to VEGF-C and VEGF-D in lymphatic endothelial cells, and plays an important role in regulation of lymphangiogenesis [30, 31].”
• Specialization of tumour vasculature (2002, neutral): “cgi?l=8828">neuropilin-2 , whereas lymphatic vessels in internal tissues do not, or do so at a level that is undetectable by current immunohistochemical method”
• Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “VEGFR-3 activation leads to induction of PI3K and stimulation of Akt/PKB, which could be important for the survival of blood and lymphatic endothelial cells (Makinen et al., 2001).”