Cradle-loop barrels and the concept of metafolds in protein classification by natural descent.

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Definition and classification of evaluation units for tertiary structure prediction in CASP12 facilitated through semi‐automated metrics (2018, background): “Numerous substantiated homologs with different barrel topologies belong to the cradle-loop metafold, including other examples of homologs with flipped hairpins and circular permutations.(16) Given the nature of this metafold, the MreC template probably represents a homology relationship to the T0866”
Protein sequence comparison and fold recognition: progress and good-practice benchmarking. (2011, unknown): “the limit of detectable sequence similarity [3, 4].”