Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.

By David W. Litchfield. Biochemical Journal, 2003

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CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response (2003, neutral): “…signals that are gener- or two suggests that CK2 is a stress-activated protein ated independently of DNA damage (Devary et al., 1993). kinase that may participate in the transduction of surThe mechanism of AP-1 activation in response to UV vival signals (Ahmed et al., 2002; Litchfield, 2003).”
An Extensive Survey of CK2 α and β Subunits in Arabidopsis: Multiple Isoforms Exhibit Differential Subcellular Localization (2006, background): “CK2 is structured as a tetrameric complex formed by two catalytic subunits (a) and two regulatory subunits (b) (Niefind et al. 2001, Litchfield 2003).”
Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation. (2013, background): “As a signaling protein, CK2 is a promiscuous kinase that has many cellular functions associated with a wide repertoire of substrates located in a variety of cellular compartments (Duncan et al., 2010; Litchfield, 2003; Pinna, 2002).”