CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.

By T. Fehniger, M. Cooper, G. Nuovo, M. Cella, F. Facchetti, M. Colonna, M. Caligiuri. Blood, 2003

907 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface (2006, background): “We suggest that the combination of the ability of cells of the CD56 bright NK subset to function as potent cytokine producers in the periphery together with their low and inefficient cytotoxic abilitie”
Functions of natural killer cells (2008, background): “In humans, the lymph nodes, where CD4 + T cells and NK cells interact, might be the location where T cell–derived IL-2 boosts NK cell”
Pre-activation with IL-12, IL-15, and IL-18 induces CD25 and a functional high affinity IL-2 receptor on human cytokine-induced memory-like NK cells (2014, background): “Signals via the Induced IL-2Rabg on Costimulate IFN-g Production In resting CD56bright NK cells, CD25 is required for picomolar concentrations of IL-2 to act in concert with IL-12 for IFN-g production [24].”
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming (2004, background): “However, some circulating NK cells express the lymph node homing receptors CD62L and CCR7, and CD56-expressing noncytolytic NK cells have been identified in human peripheral lymph node”
Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells. (2016, background): “However, the cytolytic functions of CD56brightCD16– NK cells increase when these cells are activated (56).”