Transcription Profiling-Based Identification ofStaphylococcus aureus Genes Regulated by the agrand/or sarA Loci

By P. Dunman, E. Murphy, S. Haney, D. Palacios, G. Tucker-Kellogg, S. Wu, E. Brown, R. Zagursky, D. Shlaes, S. Projan. Journal of Bacteriology, 2001

647 citations recorded by the source corpus.

Subfields: Genetics, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/01094449f376c31768997fc78382c4563abb5003

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Citations in the corpus

agr-Mediated Dispersal of Staphylococcus aureus Biofilms (2008, background): “Considering the agr system regulates the secreted proteases [45,46], we hypothesized that increased expression of extracellular proteases could be responsible for biofilm detachment.”
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology (2018, background): “These regulons of pathogenesis include Agr (336), ArlRS (337), SaeRS (338), YhcSR/AirSR (339, 340), Sar (336), SigB (341), Rot (342), and Mgr (343), among others.”
Autoinduction and signal transduction in the regulation of staphylococcal virulence (2003, background): “…58.3 Phenol-soluble modulin beta 2 6.2 treP Phosphotransferase system IIC component 13.1 treA Alpha-glucosidase 10.8 ssaA Secretory antigen precursor 17.0 hla α-Haemolysin 38.8 a. Transcript level during post-exponential phase divided by level during early exponential phase (Dunman et al., 2001).”
Quorum sensing in staphylococci. (2008, background): “signaling module: the standard bacterial signal transducing module, consisting of a membrane-bound receptor-histidine kinase (HPK) and a cytoplasmic response regulator (RR) nential increase in expression of the P2 operon, RNAIII, and the several hundred RNAIIIupregulated genes ( 33 ), it entails a t”
Bacterial quorum sensing: its role in virulence and possibilities for its control. (2012, background): “RNAIII has the dual-function of activating production of a-toxin and repressing expression of rot, fibronectin binding proteins A and B, protein A, coagulase, and other surface proteins (Morfeldt et al. 1995; Dunman et al. 2001).”
Microarray-Based Analysis of the Staphylococcus aureus σB Regulon (2004, methodology): “Although appealing, this assumption remains speculative, as both Dunman et al. ( 16 ) and Ziebandt et al. (84) used the rsbU-defective RN6390 lineage as the genetic background for their analyses, leaving it open to question what might happen with respect to the sarA regulon in strains carrying an in”
ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus. (2007, background): “SarA is a major global regulator of a diverse range of virulence determinants in S. aureus (Cheung & Zhang, 2002), with gene chip analysis revealing that this protein can affect the transcription of at least 120 genes in S. aureus (Dunman et al., 2001).”
Staphylococcal biofilms (2018, background): “Agr in staphylococci controls two main biofilm structuring and dispersal factors described above, PSMs and proteases, with the control of psm genes being exceptionally direct and tight (8, 89, 90).”