Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

By C. Gialeli, A. Theocharis, Nikos Karamanos. The FEBS Journal, 2011

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Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances (2018, background): “Several important processes of carcinogenesis, which include, but are not limited to, migration, invasion, metastasis, and angiogenesis, are closely related to the extracellular environment [63].”
ERK/MAPK signalling pathway and tumorigenesis (2020, background): “Matrix metalloproteinases (MMPs) are proteolytic enzymes that hydrolyse the extra-cellular matrix (ECM), which is one of the most important processes in the invasion and metastasis of cancer cells (107).”
Extracellular matrix structure. (2016, background): “degrading ability, MMPs, along with ADAMs and ADAMTSs dispose growth factors and cytokines to the ECM, whereas their actions on matrix molecules, including collagen, elastin, various PGs, cell membrane molecules such as integrins and receptors, generate bioactive molecules the so called matrikines [”
Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer (2011, background): “However, a positive role for DOK1 has been demonstrated in cell adhesion, cell spreading, and cell migration (Hosooka et al., 2001; Master et al., 2001; Noguchi et al., 1999; Woodring et al., 2004).”
Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “MMPs are known as protein family and classified into different evolutionary groups according to their primary sequences [267].”