Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.

By P. Siegel, J. Massagué. Nature Reviews. Cancer, 2003

768 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. (2009, background): “TGFb1 is a key player in epithelial-mesenchymal transitions and tumor invasion (Dumont and Arteaga, 2003; Massague, 2008; Massague et al., 2000; Siegel and Massague, 2003; Thiery, 2002).”
The logic of TGFβ signaling (2006, unknown): “immune surveillance [93–95] and metastasis [86,87,96,97] (Fig.”
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. (2007, background): “Our results suggest that hexosamine/N-glycan branching may differentially regulate EGFR/PI3K/ERK and TGF-b/ SMAD signaling, which are antagonistic for G1/S transition (Matsuura et al., 2004; Siegel and Massague, 2003).”
Molecular definition of breast tumor heterogeneity. (2007, background): “…activated in CD44+ breast cancer cells is the TGF-b signaling pathway, known to play an important role in human embryonic stem cells as well as in tumorigenesis (James et al., 2005; Moses and Serra, 1996; Muraoka-Cook et al., 2005; Roberts and Wakefield, 2003; Siegel and Massague, 2003).”