Does the brain have a baseline? Why we should be resisting a rest

By Alexa M. Morcom, Paul C. Fletcher. NeuroImage, 2007

376 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/002501df76e2e1539468af4b72c7b50d268c9b73

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Combined diffusion-weighted and functional magnetic resonance imaging reveals a temporal-occipital network involved in auditory-visual object processing (2013, background): “Although it is disputed whether this resting state activity reflects a task-independent default brain state or just another task-specific activity (Morcom and Fletcher, 2007), it should be considered when examining non-linear interactions.”
Transient and linearly graded deactivation of the human default-mode network by a visual detection task (2008, neutral): “…has been much debate in the literature regarding the nature of theDMNandwhether it is useful conceptually to talk of brain areas deactivating from the resting state (Stark and Squire, 2001; Morcom and Fletcher 2006; Buckner and Vincent, 2007; Raichle and Snyder 2007; Morcom and Fletcher, 2007).”
The Brain's Default Network (2008, background): “(For recent discussion of this ongoing debate see Morcom and Fletcher 2007, Buckner & Vincent 2007, Raichle & Snyder 2007).”
The maturing architecture of the brain's default network (2008, background): “Although many argue that the default network is in some way related to internally directed mental activity (3, 7, 10), this argument is not universally accepted (5, 6, 14, 15).”
Shared Neural Circuits for Mentalizing about the Self and Others (2010, background): “First, as Morcom and Fletcher (2007) point out, the cognitive/ psychological nature of what happens in the DMN at rest is unknown, and thus interpretations of well-controlled task-specific differences in signal change (as in the current study) stand relatively independently of what they mean in…”
The Brain’s Default Network and its Adaptive Role in Internal Mentation (2011, neutral): “A current matter of debate is whether default network activity during resting states reflects the network’s absolute baseline level of neural activity or whether the default network increases its activity above absolute baseline during rest because individuals engage in mental activity when attentio”
Que PASA? The posterior-anterior shift in aging. (2008, background): “Although this idea has been challenged (Morcom and Fletcher 2006), understanding deactivations within these regions is very important because of evidence that these deactivations are necessary for successful performance in healthy younger adults (Daselaar et al. 2004) and may reﬂect a reallocation…”
Unrest at rest: Default activity and spontaneous network correlations (2007, background): “In a recent commentary, Morcom and Fletcher (2007) question the utility of studying rest activity from a number of perspectives.”
Can brain state be manipulated to emphasize individual differences in functional connectivity? (2017, background): “Rest is a task in and of itself, just an unconstrained one (Morcom and Fletcher, 2007).”
Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. (2010, background): “Some authors have even questioned the value and interpretability of spontaneous brain activity fluctuations as recorded by fMRI (Morcom and Fletcher, 2007).”
A default mode of brain function: A brief history of an evolving idea (2007, background): “Illustrative in this regard is the opinion that “the suggested link between the processing taking place at rest and its physiology is one that can have no direct relevance for neuroimaging” (Morcom and Fletcher, 2007).”
Functional connectivity of human striatum: a resting state FMRI study. (2008, background): “The absence of a plausible model has led to skepticism regarding this approach ( Morcom and Fletcher 2006 ), despite accumulating evidence that it is a robust (Buckner and Carroll 2007), stable (Damoiseaux et al. 2006) and intriguingly revealing technique (Margulies et al. 2007).”
Resting State fMRI: A Personal History (2012, background): “As to be expected with this proliferation (and, indeed, as was present from the outset), there has been some strong criticisms of the resting-state paradigm (e.g., Morcom and Fletcher, 2007).”
Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness (2010, background): “It has been suggested that coherent spontaneous blood oxygen level-dependent (BOLD) fluctuations observed in the resting state reflect unconstrained but consciously-directed mental activity.(29) These fluctuations were then found to persist in situations of reduced consciousness, such as in anesthet”
Effects of aging on functional and structural brain connectivity☆ (2017, background): “The neural validity of resting state functional connectivity has been debated (Morcom and Fletcher, 2007), but comparisons of electrophysiological recordings and resting state functional MRI data provide support for a neural correlate of these connectivity patterns (Nir et al., 2008; Ossandón et…”
Toward discovery science of human brain function (2010, background): “Buttressed by moderate to high test–retest reliability (8–10) and replicability (11, 12), as well as widespread access, R-fMRI has overcome initial skepticism (13) regarding the validity of examining such an apparently unconstrained state (5, 8, 14).”