Faculty Opinions recommendation of Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
By M. Fukuda, Xingfeng Bao. 2012
1,176 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/0019a2330c623178947768fad31d7738620da0fc
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- Lifeng Yang
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- Yusuke Nakamura
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Citations in the corpus
- Metabolic reprogramming and cancer progression (2020, background): “F. Skoulidis et al., Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.”
- KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer (2018, background): “ERK MAPK-directed regulation of MYC also drives the expression of genes that support the elevated glucosemetabolism inKras-mutant mouse PDAC cells in vivo (Ying et al. 2012).”
- Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids (2013, background): “Like PI3K-Akt pathway activation, Ras activation induces glucose uptake and lactate excretion (20).”
- The Consensus Molecular Subtypes of Colorectal Cancer (2015, methodology): “is supported by grants from the Dutch Cancer Society (UVA2011-4969, UVA2014-7245), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03) and the European Research Council (ERG-StG 638193).”
- Reprogramming of fatty acid metabolism in cancer (2019, background): “For instance, mutant KRAS enhances glycolysis in pancreatic cancer cells through upregulation of the genes encoding hexokinase 1/2 (Hk1 and Hk2, respectively), and redirects glutamine flux to malate for the production of pyruvate and reducing power in the form of NADPH.58,59 Moreover, amplification ”
- Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016, methodology): “To further substantiate the role of KRAS, we used doxycycline inducible Kras-G12D cell line (iKras-1, [Ying et al., 2012]) to test if enhancement of proliferation by CDEs indeed was KRAS independent.”
- Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention (2017, background): “In pancreatic cancer, the Warburg effect has been shown to be an early event in carcinogenesis, induced by activation of oncogenic Kras (11).”