Statin use and reduced cancer-related mortality.

By S. F. Nielsen, Børge G. Nordestgaard, S. Bojesen. New England Journal of Medicine, 2012

961 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/00164b9f8926eb5e0f1bc150a9dd8e8202b8462d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

D. Leroith

In Surgery

Citations in the corpus

Cholesterol induces CD8+ T-cell exhaustion in the tumor microenvironment (2019, positive): “, 2016), reduce cancer-related mortality by 15% (Nielsen et al., 2012), and reduce risk of tumor recurrence in patients with breast cancer (Chae et al.”
Shared Risk Factors in Cardiovascular Disease and Cancer (2016, background): “Strong evidence demonstrates improvement in disease-free survival in breast cancer survivors who were on statins at the time of diagnosis.(14,98) Similarly, mounting evidence shows that prediagnostic statin use reduces the risk of lethal prostate cancer.”
Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. (2015, background): “Recent studies have reported that cholesterol-lowering therapy, with 3-hydroxy-3-methyl-glutaryl-CoA (HMG CoA) reductase inhibitors, is associated with a lower risk of overall cancer mortality (145), with some studies reporting a lowering risk of developing specific cancers, including hepatocellular”
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity (2020, background): “Patients who have taken statins for more than 5 years exhibit a 47% decreased risk of colorectal cancer than non-statin users after adjusting for confounding factors [153].”
Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management (2015, neutral): “Furthermore, increased prescription of statins itself appears to be associated with increased non-adherence or discontinuation, as illustrated for Denmark over the period 1995–2010 (Figure 1).(26,27) Different factors may have contributed to this finding.”
Use of statins and the risk of death in patients with prostate cancer. (2014, background): “To date, a number of observational studies have examined the association between statins and prostate cancer outcomes, with mixed findings.(2-11) Disease recurrence was the primary outcome in the majority of these studies,(8,9) with two studies reporting null associations(8,9) and the remaining stud”