Natural history of potentially malignant oral lesions and conditions: an overview of the literature.

By S. Napier, P. Speight. Journal of Oral Pathology & Medicine, 2007

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Oral cavity and oropharyngeal squamous cell carcinoma—an update (2015, background): “4).(116,125-127) However, even the most innocuous leukoplakias can show significant dysplastic changes or even invasive carcinoma; therefore, biopsy is usually recommended for most unexplained oral white lesions (Fig.”
Global epidemiology of oral and oropharyngeal cancer. (2009, background): “Therefore, screening for premalignant or early stage oral cancers is worthy of consideration.(62) Several large population screening programmes from SE Asia and smaller studies from England and Japan were reported during the period 1980–2000.”