Bacterial siderophores in community and host interactions
By Jos Kramer, Özhan Özkaya, R. Kümmerli. Nature Reviews Microbiology, 2019
779 citations recorded by the source corpus.
Iron is an essential trace element for most organisms. A common way for bacteria to acquire this nutrient is through the secretion of siderophores, which are secondary metabolites that scavenge iron from environmental stocks and deliver it to cells via specific receptors. While there has been tremendous interest in understanding the molecular basis of siderophore synthesis, uptake and regulation, questions about the ecological and evolutionary consequences of siderophore secretion have only recently received increasing attention. In this Review, we outline how eco-evolutionary questions can complement the mechanistic perspective and help to obtain a more integrated view of siderophores. In particular, we explain how secreted diffusible siderophores can affect other community members, leading to cooperative, exploitative and competitive interactions between individuals. These social interactions in turn can spur co-evolutionary arms races between strains and species, lead to ecological dependencies between them and potentially contribute to the formation of stable communities. In brief, this Review shows that siderophores are much more than just iron carriers: they are important mediators of interactions between members of microbial assemblies and the eukaryotic hosts they inhabit. Secreted siderophores help bacteria to take up iron from the environment. In this Review, Kramer, Özkaya and Kümmerli discuss the functions and implications that siderophores have for social interactions between bacterial cells and the resulting consequences for communities and hosts.
Subfields: Genetics, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/ff929098c89057c374295b507a92e5c076b1919c
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Citations in the corpus
- Rhizosphere Engineering With Plant Growth-Promoting Microorganisms for Agriculture and Ecological Sustainability (2021, background): “At neutral and alkaline pH, it exists in oxidized ferric (Fe3+) form which is highly insoluble and inaccessible for plants (Kramer et al., 2019).”