Garbage Truck of the Brain
By Maiken Nedergaard. Science, 2013
602 citations recorded by the source corpus.
An intercellular “glymphatic” pathway clears cell waste from the brain and may reveal new targets for treating neurodegenerative diseases. Essentially all neurodegenerative diseases are associated with misaccumulation of cellular waste products. Of these, misfolded or hyperphosphorylated proteins are among the most difficult for the brain to dispose. For example, tau and β-amyloid can accumulate as stable aggregates that are neurotoxic in conditions such as Alzheimer's disease (1). Intracellular proteasomal degradation and autophagy are considered the principal means for removing proteins in the central nervous system, and the dysfunction of each has been causally associated with neurodegeneration (2).Yet many cytosolic proteins are released into the interstitial space in the brain, suggesting that extracellular disposal routes may also eliminate waste (3).
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/ff496240524249e259df826d1902efb96bccd1ee
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Neurology
Citations in the corpus
- Astrocyte roles in traumatic brain injury (2015, background): “…with nearly all neurovascular basal lamina of the CNS is central to a selectively permeable blood brain barrier (Abbott et al., 2006), as well as the efficient exchange of cerebrospinal and interstitial fluid by the more recently described glymphatic system (Iliff et al., 2012; Nedergaard, 2013).”