De novo design of a Zn2+-binding protein

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Hallucinating protein assemblies (2022, background): “Because of the many applications of cyclic protein oligomers, ranging from small molecule binding and catalysis to building blocks for nanocage assemblies( 5 ), de novo design of such structures has been of considerable interest from the beginning of the protein design field ( 6 , 7 ).”
De novo protein design, a retrospective (2020, background): “Furthermore, structure-stabilizing disulfides (Regan et al., 1994) and metal-binding sites (Handel and DeGrado, 1990; Regan and Clarke, 1990; Handel et al., 1993) were successfully introduced into the tertiary structure, as confirmed by NMR (Handel and DeGrado, 1990; Handel et al., 1993).”
The protein folding problem. (2008, background): “Novel proteins are now designed as variants of existing proteins (43,94,99,145,173,243), or from broadened alphabets of nonnatural amino acids (226), or de novo (129) (Figure 2).”