Chromosome-Encoded Ambler Class A β-Lactamase of Kluyvera georgiana, a Probable Progenitor of a Subgroup of CTX-M Extended-Spectrum β-Lactamases

By L. Poirel, Peter Kämpfer, P. Nordmann. Antimicrobial Agents and Chemotherapy, 2002

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Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. (2015, result): “In addition, the gene sequences adjacent to the CTX-M genes of Enterobacteriaceae are also similar to those surrounding the b-lactamase genes on the chromosomes of Kluyvera species (Olson et al., 2005; Humeniuk et al., 2002; Poirel et al., 2002).”
CTX-M Enzymes: Origin and Diffusion (2012, background): “Chromosomal bla gene, kluC, present in Kluyvera cryocrescens has been considered the ancestor of the CTX-M-1 cluster (Decousser et al., 2001), kluA gene from Kluyvera ascorbata the origin of the CTX-M-2 cluster (Humeniuk et al., 2002) and three different chromosomal bla genes from Kluyvera georgiana”