Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study.

By M. Mccredie, K. Sharples, C. Paul, J. Baranyai, G. Medley, Ronald W. Jones, D. Skegg. The Lancet Oncology, 2008

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American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. (2012, positive): “We used detection of CIN3 as the measure of a screening test’s sensitivity for precancer because a substantial proportion of women with CIN3 would develop invasive cervical cancer if left untreated.(18) Also, given the natural history of cervical carcinogenesis and the relative rarity of cervical ca”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “7% for women whose initial treatment for CIN3 was considered adequate (McCredie et al., 2008).”
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations From the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology (2012, background): “The 30year progression risk of invasive cancer is 30% to 50% for untreated high-grade cervical disease [11, 12].”