Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

By Bharat B. Aggarwal, R.V. Vijayalekshmi, Bokyung Sung. Clinical Cancer Research, 2009

769 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/fe9d34c727d4c168c194dcf95d8a3318b33b7adc

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Citations in the corpus

MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. (2010, background): “to inflammation-associated malignancy (34), is activated by miR-155 (Fig.”
Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. (2014, background): “for the association of high NLR with worse OS to be greater for metastatic than nonmetastatic disease and may reflect either greater tumor burden or a more prolonged chronic inflammatory process (3).”
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “Butein has been traditionally used for the treatment of pain, thrombotic disease, gastritis, stomach cancer, and parasitic infections in Korea, Japan, and China and so far no reports have suggested the toxicity of this polyphenol [3].”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “chemicals; autoimmune and chronic diseases; obesity; consumption of alcohol; tobacco use; and a high-calorie diet [60,67].”
The Role of Resveratrol in Cancer Therapy (2017, background): “In preclinical models, lung carcinogenesis is known to be induced by a variety of agents, including diethylnitrosamine (DEN), nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), uracil mustard, vinyl carbamate, urethane, MNU, and BP [11].”
Exposure to Political Violence and Political Extremism (2013, background): “Since the down-regulation of the immune system and inflammation are associated with various diseases (Gouin et al., 2012; Maggio-Price et al., 2006; Aggarwal et al., 2009), these physiological symptoms of chronic stress have important implications for the longterm health of societies in conflict.”
Immunity, Inflammation, and Cancer (2010, neutral): “Tumor-promoting inflammation can be targeted in several different ways: (1) inhibition of signal transducers and transcription factors that mediate survival and growth of malignant cells in response to inflammatory cytokines; (2) sequestration of chemokines and cytokines that recruit and sustain inf”
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “…vascular endothelial growth factor (VEGF) and its receptors, platelet-derived growth factor, ﬁbroblast growth factors, epidermal growth factor (EGF), ephrins, angiopoietins, en-dothelins, integrins, cadherins, and transcription factors ( e.g. , AP-1, NF-j B) (3, 5, 103, 183, 229, 323) (Table 4).”
Inflammation and Cancer (2019, background): “Two pathways have been schematically identified: in the intrinsic pathway, genetic events causing neoplasia initiate the expression of inflammation-related programs that guide the construction of an inflammatory microenvironment, and in the extrinsic pathway, inflammatory conditions facilitate cance”