Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

By M. Thien, T. Phan, Sandra Gardam, Michelle Amesbury, A. Basten, F. Mackay, R. Brink. Immunity, 2004

788 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/fe229b362c7bf2b55697edc641df60ee25bfb1b0

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In Immunology

1. Jacques Banchereau
2. V. Pascual
3. F. Mackay
4. K. Palucka
5. Rafi Ahmed
6. Bali Pulendran

Citations in the corpus

• Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “BAFF is induced by IFN-ab and contributes to the survival of peripheral B cells, inlcuding those expressing autoreactive B cell receptors (Thien et al., 2004).”
• Cracking the BAFF code (2009, background): “However, the use of animal models mimicking the natural competition between healthy and self-reactive B cells has not revealed any catastrophic breakdown of B cell tolerance or massive escape of high-affinity autoreactive B cells in Baff -transgenic mic”