Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians
By A. Huerta-Alardin, J. Varon, P. Marik. Critical Care, 2004
902 citations recorded by the source corpus.
Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration.
Subfields: Psychiatry and Mental health, Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/fdf5a099c35f85b898ff2e4093c277d5ee391052
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Citations in the corpus
- A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation (2010, background): “In general, it seems likely that the cause lies in the breakdown of sodium/calcium homoeostasis in the muscle cell (Huerta-Alardin et al. 2005).”
- Creatine-Kinase- and Exercise-Related Muscle Damage Implications for Muscle Performance and Recovery (2012, background): “Measurement of serum CK activity and determination of isoenzyme profiles are still an important indicator of the occurrence of muscle cell necrosis and tissue damage due to disease or trauma [3].”
- Detection of Pharmacovigilance-Related adverse Events Using Electronic Health Records and automated Methods (2012, methodology): “19 In utilizing EHR data for signal detection, if an abnormal finding such as rhabdomyolysis is the basis for extracting data on potential patients, the SADR cases must be separated from those arising from other causes.”