Targeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia
By K. Tam, K. Lacey, J. Devlin, M. Coffre, Alexis G. Sommerfield, Rita Chan, Aidan O’Malley, Sergei B Koralov, P. Loke, Victor J. Torres. 2020
31 citations recorded by the source corpus.
Staphylococcus aureus secretes pore-forming leukocidins that kill leukocytes as part of the bacterium’s evasion strategy. Leukocidin-based vaccination results in toxin-neutralizing antibodies and toxin-specific CD4 lymphocytes that block the toxins and boost host-mediated antimicrobial responses to protect mice from bloodstream infection.
Subfields: Immunology, Infectious Diseases, Microbiology
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In Immunology
In Infectious Diseases
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Citations in the corpus
- Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes (2020, background): “Moreover, the identification of the LukE DR1 as critical for toxin activity pinpoints a domain that could be used to elicit protective immune responses in the form of neutralizing antibodies (41).”