Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution,…

By You Han Bae, N. Nishiyama, S. Fukushima, H. Koyama, Matsumura Yasuhiro, Kazunori Kataoka. Bioconjugate chemistry, 2005

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Polymers for Drug Delivery Systems (2010, background): “Previous studies from the same group showed intracellular pH-triggered release capability with the same micellar system synthesized without folate: No appreciable drug was released at physiological pH whereas release was observed once the pH decreased below pH = 6 (109).”
Nanocarriers’ entry into the cell: relevance to drug delivery (2009, background): “The micelles formed by this copolymer were taken up in vitro by the cells of a multicellular tumor spheroid, and the released drug was observed to accumulate in the cell nuclei, suggesting that escape from endo/lysosomes has taken place [127].”
Polymer conjugates as anticancer nanomedicines (2006, background): “Another interesting related field is block copolymer micelles as carriers for chemotherap”