Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine.

By A. Bradwell, H. Carr-Smith, G. Mead, Lian X. Tang, P. Showell, M. Drayson, R. Drew. Clinical Chemistry, 2001

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Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis (2005, background): “Although the normal value for the free light chain is 3–4 mg/dL [99], values that are only slightly above this can decrease into the normal range because of laboratory variation [100].”
Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis (2016, neutral): “This contrasts with variant ATTR amyloidosis and AL amyloidosis, which are supported by the presence of a TTR gene mutation(33) or monoclonal immunoglobulin, respectively.(31,32) Currently, wild-type ATTR amyloidosis is diagnosed mostly in men >70 years of age and in <3 per million per year,(35) whi”
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders (2009, neutral): “In the early 2000s an assay that measured serum immunoglobulin-free light chains (FLC) was developed.(1) This assay differentiated itself from prior light chain reagents that were called quantitative light chain measurements in that these novel polyclonal antibodies reacted with only those epitopes ”