On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system
By A. Adamo, Rachel L. Beingessner, M. Behnam, Jie Chen, T. Jamison, Klavs F. Jensen, J. Monbaliu, A. Myerson, E. Revalor, D. Snead and 4 more. Science, 2016
777 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fcfe61c837902538ffbb638e16a9f5410a57495e
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Citations in the corpus
- Automating drug discovery (2017, methodology): “…synthesis of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam and fluoxetine hydrochloride in qualities that meet US Pharmacopeia standards 97 . or telescoped preparative ES, yielding up to 47% conversion of the starting material to atropine in residence times of a few minutes.”
- Autonomous chemical research with large language models (2023, neutral): “Examples range from the autonomous discovery 17,18 and optimization of organic reactions 19 to the development of automated flow systems 20,21 and mobile platforms 22 .”
- A robotic platform for flow synthesis of organic compounds informed by AI planning (2019, methodology): “Whereas flow chem-istryplatformshavebeendevelopedforautomatedscreening,optimization,andproduction( 5 , 7 , 22 – 24 ), they require manual reconfiguration to the exact flow path required for each process.”