Integrins Regulate Rac Targeting by Internalization of Membrane Domains

By M. A. del Pozo, Nazilla B. Alderson, W. Kiosses, Hui-Hsien Chiang, R. G. Anderson, M. Schwartz. Science, 2004

603 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/fcfcbf624e38638abfb19d599f775a3775b838f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. S. Millard
2. S. Mitra
3. Daniel A. Hanson
4. S. Wood
5. K. Legate
6. D. Schlaepfer
7. R. Fässler
8. S. Wickström

In Immunology and Allergy

1. S. Mitra
2. Daniel A. Hanson
3. K. Legate
4. D. Schlaepfer
5. R. Fässler
6. S. Wickström

Citations in the corpus

• GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo (2007, background): “In the case of Rac1, its residence at the plasma membrane requires in some instances integrin-dependent signals that block the co-internalization of the GTPase with lipid rafts(25) (Fig.”
• Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “On the other hand, rapid internalization of rafts in response to changes in integrin ligand occupancy can effectively turn off entire signaling modules (del Pozo et al. 2004).”
• Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, positive): “Plasma membrane rafts containing Rac1 are known to be internalized in response to integrin signals (del Pozo et al., 2004), and caveola-derived signaling endosomes, which are a type of membrane-derived " signalosome, " continue to transduce growth factor receptor signals after internalization.”
• A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells (2005, background): “Moreover, very recent studies by Schwartz and colleagues demonstrate that integrin signals regulate lipid raft formation and Rac1 targeting to newly synthesized rafts (del Pozo et al., 2004), although the nature of the integrin activating signal is not explored.”
• Focal adhesion kinase: in command and control of cell motility (2005, background): “This regulation of a distinct membrane lipid environment by FAK or integrin signallin”