Stress granules and cell signaling: more than just a passing phase?
By N. Kedersha, P. Ivanov, Paul Anderson. TIBS -Trends in Biochemical Sciences. Regular ed, 2013
604 citations recorded by the source corpus.
Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As signaling centers, SG formation communicates a “state of emergency”, and their transient existence alters multiple signaling pathways by intercepting and sequestering signaling components. SG assembly and downstream signaling functions may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fce888452e24d492c4f9709f10823c025670e356
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Citations in the corpus
- Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly (2017, background): “Second, RNP granules are often enriched in proteins with IDRs (Decker et al., 2007; Jain et al., 2016; Kato et al., 2012; Kedersha et al., 2013; Reijns et al., 2008).”
- The stress granule transcriptome reveals principles of mRNA accumulation in stress granules (2017, neutral): “It remains possible that sequestering 10%–13% of the mRNAs in the cell has other impacts on cell physiology, such as affecting signaling pathways (Kedersha et al., 2013).”
- Protein Phase Separation: A New Phase in Cell Biology (2018, background): “SGs form reversibly when cells are stressed and it is thought that the formation of SGs is a form of stress response [62].”
- Distinct stages in stress granule assembly and disassembly (2016, background): “Stress granules are thought to influence mRNA function, localization, and to affect signaling pathways (Buchan, 2014; Buchan and Parker, 2009; Kedersha et al., 2013).”