Diminishing returns epistasis among beneficial mutations decelerates adaptation
By H. Chou, Hsuan-Chao Chiu, N. F. Delaney, Daniel Segrè, C. Marx. 2011
512 citations recorded by the source corpus.
Interactions between genes reduce the benefits of a mutation and decrease the rate of fitness gain during adaptation. Epistasis has substantial impacts on evolution, in particular, the rate of adaptation. We generated combinations of beneficial mutations that arose in a lineage during rapid adaptation of a bacterium whose growth depended on a newly introduced metabolic pathway. The proportional selective benefit for three of the four loci consistently decreased when they were introduced onto more fit backgrounds. These three alleles all reduced morphological defects caused by expression of the foreign pathway. A simple theoretical model segregating the apparent contribution of individual alleles to benefits and costs effectively predicted the interactions between them. These results provide the first evidence that patterns of epistasis may differ for within- and between-gene interactions during adaptation and that diminishing returns epistasis contributes to the consistent observation of decelerating fitness gains during adaptation.
Subfields: Genetics, Public Health, Environmental and Occupational Health, Sociology and Political Science
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In Genetics
- Martin Weigt
- Matteo Figliuzzi
- Alexander Schug
- Joshua B. Plotkin
- Jakub Otwinowski
- Shamil R. Sunyaev
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In Public Health, Environmental and Occupational Health
In Sociology and Political Science
Citations in the corpus
- Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 (2015, background): “[9] Hsin-Hung Chou, Hsuan-Chao Chiu, Nigel F Delaney, Daniel Segrè, and Christopher J Marx.”
- Global Epistasis Makes Adaptation Predictable Despite Sequence-Level Stochasticity (2014, background): “Related work has provided evidence for such patterns among particular small sets of mutations that arise in a single experimental line (22, 23).”
- Should evolutionary geneticists worry about higher-order epistasis? (2013, unknown): “0 1 2 3 4 Epistatic Order Methalobacterium extorquens beneficial mutations in novel metabolic pathway [19]”
- The mystery of missing heritability: Genetic interactions create phantom heritability (2012, background): “(21) have recently demonstrated clear epistasis among collections of five mutations that increase growth rate.”
- Inferring fitness landscapes by regression produces biased estimates of epistasis (2014, background): “One measure of epistasis, which reflects the degree of predictability in adaptation, is to reconstruct all the possible genetic paths between a low-fitness ancestral genotype and a high-fitness derived genotype sampled from an experimental population [66, 31, 18, 67, 33, 68, 69, 24, 36] The proporti”