Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing.

By Jordi García-Ojalvo, Michael B. Elowitz, Steven H. Strogatz. Proceedings of the National Academy of Sciences of the United States of America, 2004

595 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fc1bec7902ed157a342237ac7889f4c86db03eae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, result): “Our results, which underscore the importance of intercellular communication in the SCN, serve as an experimental validation of model predictions previously made in the context of a simple synthetic system, where the same general principle was observed (Garcia-Ojalvo et al., 2004).”
A synchronized quorum of genetic clocks (2010, unknown): “Furthermore, theoretical work has shown how the introduction of an autoinducer in similar designs can potentially lead to synchronized oscillations over a population of cells 40,41 .”
Oscillation quenching mechanisms: Amplitude vs. oscillation death (2013, background): “Therefore, several theoretical [70,71,43,72,59] and experimental models [68,73,74] of distinct synthetic oscillators or populations have been investigated in the literature.”
Colloquium: Criticality and dynamical scaling in living systems (2017, background): “…the following non-exhaustive list of examples: (i) synchronization phase transitions in collective biological oscillators such as circadian clocks (Garcia-Ojalvo et al., 2004); (ii) percolation transitions of fibers in connective tissues such as collagen (Alvarado et al., 2013; Forgacs et al.,…”
Synchronization in complex networks (2008, background): “Garćıa-Ojalvo et al. (2004) recently proposed a simple modular addition of two proteins to the repressilator original design that could be used to describe the metabolic oscillations observed in a well mixed suspension of yeast cells.”
Bistability, epigenetics, and bet-hedging in bacteria. (2008, background): “Synthetic biology also allows the creation of entirely new, or rerouted, networks, such as toggle switches, oscillatory networks, and even synthetic multicellular clocks based on quorum sensing (10, 27, 34, 36).”