HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

By P. Kwong, M. Doyle, David J. Casper, C. Cicala, Stephanie A. Leavitt, Shahzad Majeed, Tavis D. Steenbeke, M. Venturi, I. Chaiken, M. Fung and 11 more. Nature, 2002

957 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Virology

View Paper: https://www.semanticscholar.org/paper/fc1675b49c4a1332f723e8a5cae5abae3708a85e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Fang Li

In Radiology, Nuclear Medicine and Imaging

1. Barney S. Graham
2. Fang Li

In Virology

1. Beatrice H. Hahn
2. Fang Li

Citations in the corpus

• Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen (2017, background): “For HIV-1 Env, the I559P substitution in gp41 helped to produce a stable ectodomain trimer designated “SOSIP” (32), which facilitated Fig.”
• Role of pyroptosis in inflammation and cancer (2022, background): “However, HIV can evade the perception of CARD8, as its protease remains inactive before the virus buds in the infected cells [92].”
• Cell entry mechanisms of SARS-CoV-2 (2020, background): “Briefly, HEK293T cells were cotransfected with a plasmid carrying an Env-defective, luciferase-expressing HIV-1 genome (pNL4-3.luc.”
• Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies (2005, background): “Due to the extraordinary degree of genetic diversity of HIV-1 and the structural complexity of its envelope glycoproteins (Env) (54, 118), designing an effective vaccine is difficult.”
• Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1 (2014, background): “Crystallographic studies have revealed that VRC01, and related mAbs, bind to RSC3 by virtue of their angle of approach which is rotated 45u [34] relative to that of CD4 binding observed in a co-crystal with gp120 [35].”
• Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies (2004, background): “It is likely that steric restrictions limit the access of this MAb to its epitope on the vast majority of primary viruses (13, 63, 121, 127).”