Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals.

By G. Siegle, S. Steinhauer, Michael E. Thase, V. Stenger, Cameron S. Carter. Biological Psychiatry, 2002

880 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/fba3b08e606cbdabda61a39a908fdd8031a9e047

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In Cognitive Neuroscience

In Experimental and Cognitive Psychology

Citations in the corpus

Emotion regulation in depression: Examining the role of cognitive processes (2010, background): “Investigators have found the combination of DLPFC hypoactivity and sustained amygdala activity to be related to self-reported rumination in a study that examined prolonged elaborative processing of emotional information in depression (Siegle, Steinhauer, Thase, Stenger, & Carter, 2002 ).”
Social functioning in major depressive disorder. (2016, neutral): “This hyperactivity includes sustained amygdala responses to emotional stimuli (25s in comparison to 10s in healthy controls) (Siegle et al., 2002).”
Determinants of Emotion Duration and Underlying Psychological and Neural Mechanisms (2015, background): “Nevertheless, it is notable that whereas rumination was found to sustain amygdala activation over time (Siegle et al., 2002), reappraisal and distraction reduce amygdala activity while engaging prefrontal regions important for working memory, selective attention, and cognitive control more generally”
Which emotions last longest and why: The role of event importance and rumination (2015, background): “Moreover, research on emotion dynamics is important from a clinical perspective, as disturbances in these dynamics are symptomatic of mental disorders such as depression (Siegle et al. 2002) and may lead to the development of somatic diseases such as cardiovascular illness (Brosschot et al. 2006).”
Neural mechanisms of the cognitive model of depression (2011, methodology): “but has an inverse relationship with left DLPFC activation, which is suggested to represent a system of higher-order cognitive interventio”
Neurocircuitry of Mood Disorders (2010, background): “In MDD subjects the amygdala shows exaggerated hemodynamic responses during exposure to sad words (Siegle et al, 2002), explicitly presented sad faces (Drevets et al, 2001; Fu et al, 2004), masked fearful faces (Sheline et al, 2001), and masked sad faces (Fu et al, 2004).”
High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas (2017, background): “…2012, Hortensius et al., 2016), and accordingly, its dysfunction is implicated in psychopathologies, such as mood disorders (Phillips et al., 2003; Siegle et al., 2002), anxiety disorders (Birbaumer et al., 1998; Rauch et al., 2003), and developmental disorders (Baron-Cohen et al., 2000; Dziobek…”
Facial expressions and complex IAPS pictures: Common and differential networks (2006, methodology): “Finally, this analysis assumed a canonical hemodynamic response function; however, emotions elicited by facial expressions and IAPS pictures may have different temporal dynamics (Siegle et al., 2002), and this warrants further exploration.”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “…in some depressive subtypes is thought to contribute to mitochondrial dysfunction, neuropathological changes, elevated body temperature, premature osteoporosis and aging, and other medical morbidity in individuals suffering from mood disorders (McEwen and Magarinos 2001; Gold et al. 2002).”