Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

By M. Dewan, Ashley E Galloway, N. Kawashima, J. Dewyngaert, J. Babb, S. Formenti, S. Demaria. Clinical Cancer Research, 2009

1,546 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/836f6609230dfd8eb8173d65ed1419f8edd6cc88

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. W. Zou
2. D. Pardoll
3. S. Demaria
4. S. Formenti
5. E. Golden
6. A. Chachoua
7. R. Ferris
8. Charles G. Drake

In Oncology

1. S. Demaria
2. S. Formenti
3. W. Zou
4. D. Pardoll
5. E. Golden
6. A. Chachoua
7. R. Ferris
8. Charles G. Drake

In Radiology, Nuclear Medicine and Imaging

1. S. Formenti
2. S. Demaria

Citations in the corpus

• Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, methodology): “Tumor growth experiments and TIL preparation B16-OVA melanoma and 4T1-HA breast carcinoma models were performed as previously described with somemodifications (33, 34).”
• Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. (2014, background): “of highly focused tumor targeting and reduced systemic impact on the immune system (5, 22, 26, 27).”
• Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas (2013, positive): “Of note, fractionated RT has been reported to be superior to single-session RT when used in combination with CTLA-4 (14).”
• Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11 (2019, background): “More recently, cGAS–STING sensing of cytoplasmic DNA and micronuclei following radiation has emerged as an important connection between innate immunity and radiotherapy (3, 4, 32).”
• Immunology and Immunotherapy of Head and Neck Cancer. (2015, background): “Mouse models of poorly immunogenic tumors have demonstrated that concomitant administration of anti–CTLA-4 antibodies and RT results in antitumor T-cell responses both in the radiation field and outside of it (an abscopal effect).(98,99) PD-1 blockade after completion of RT also has been shown to in”