Manufacturing Molecules Through Metabolic Engineering

By Jay D. Keasling. Science, 2010

790 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fb85aea9b67bc836182e99409bc2851f5d54f4d2

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In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Coupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand Specificity (2015, background): “Metabolic pathway engineering requires fine-tuning enzyme activity and specificity to optimize the production of small molecule products such as drugs or biofuels [1].”
Inferring Biological Networks by Sparse Identification of Nonlinear Dynamics (2016, background): “In addition, better models for metabolic networks could facilitate metabolic engineering of designer drugs using microorganisms as bio-chemical factories [30].”
Biomolecular computing systems: principles, progress and potential (2012, background): “Recently, such goals have included engineering of metabolism for bioproduction 4 ; controlling the immune system during organ transplantation 5 ; manipulating cell differentiation and spatial organization for tissue engineering 6 ; and, at the pinnacle of these efforts, controlling myriad aspects…”
Computational protein design enables a novel one-carbon assimilation pathway (2015, methodology): “…such as glucose, have been constructed in organisms that lack one-carbon anabolic pathways, such as Escherichia coli or Saccharomyces cerevisiae (1 – 3); however, despite considerable effort, it has been difficult to introduce heterologous one-carbon fixing pathways into these organisms (4).”
Engineering Cellular Metabolism (2008, positive): “Thus, the field of metabolic engineering was born (Bailey, 1991; Stephanopoulos and Vallino, 1991; Nielsen, 2001; Keasling, 2010).”