Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

By Pengyu Huang, Zhiying He, Shuyi Ji, Hua Sun, D. Xiang, Changcheng Liu, Yi-Ping Hu, Xin Wang, Lijian Hui. Nature, 2011

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Transcriptional Regulation and its Misregulation in Disease (2013, positive): “…states and that are capable of reprogramming cell states when ectopically expressed in various cell types (Buganim et al., 2012; Davis et al., 1987; Huang et al., 2011; Ieda et al., 2010; Kajimura et al., 2009; Marro et al., 2011; Pang et al., 2011; Sekiya and Suzuki, 2011; Takahashi and Yamanaka,…”
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids. (2018, positive): “Alternatively, it has been proven feasible to induce trans-differentiation of ﬁbroblasts by transfection with reprogramming genes (Huang et al., 2011; Huang et al., 2014; Swen-son, 2012; Zhu et al., 2014).”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “Indeed, FoxA3 along with GATA4 are among three factors that together can potently reprogram fibroblasts to hepatocyte-like cells (Huang et al. 2011).”