A candidate precursor to serous carcinoma that originates in the distal fallopian tube

By Yonghee Lee, A. Miron, R. Drapkin, M. Nucci, F. A. Medeiros, Aasia Saleemuddin, J. Garber, C. Birch, H. Mou, R. W. Gordon and 3 more. 2007

755 citations recorded by the source corpus.

Subfields: Epidemiology, Pathology and Forensic Medicine, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/fb379fde35af69d60f3684ad465b6682ecc992fe

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In Epidemiology

In Pathology and Forensic Medicine

F. Balkwill

In Reproductive Medicine

Citations in the corpus

The Origin and Pathogenesis of Epithelial Ovarian Cancer- a Proposed Unifying Theory (2010, background): “Based on these findings, a sequence of pathogenetic events has been proposed beginning with genotoxic DNA damage, followed by TP53 mutation and progressive loss of cell cycle control, which then eventuate in the development of carcinoma.(24) There are a number of questions that must be resolved, how”
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary (2010, background): “p53 immunostaining and mutation appear to be a feature of early-stage Fallopian tube lesions from BRCA1/2 mutation carriers [7], suggesting that p53 dysfunction is essential for early tumourigenesis of HGPSC.”
Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features (2012, background): “TIC shows strong immunoreaction for HMFG2, an antibody that recognizes mucin 1, and Stathmin 1, both markers of secretory cells, suggesting that these cells are the target for malignant transformation [16, 29].”
Rethinking Ovarian Cancer: Recommendations for Improving Outcomes (2011, positive): “For example, the distal fallopian tube has been identified as a source of high-grade serous ovarian cancer”
Molecular Pathogenesis and Extraovarian Origin of Epithelial Ovarian Cancer. Shifting the Paradigm (2011, positive): “In addition, short stretches of normal appearing fallopian tube epithelium that strongly expresses p53, and in which TP53 mutations have occasionally been identified, have been termed “p53 signatures” (68).”