Domoic acid: The synergy of iron, copper, and the toxicity of diatoms

By M. Wells, Charles G. Trick, W. Cochlan, Margaret P. Hughes, V. Trainer. 2005

212 citations recorded by the source corpus.

Subfields: Biomaterials, Environmental Chemistry, Oceanography

View Paper: https://www.semanticscholar.org/paper/fad86540d004764a996b8f2189dc5707d25f949a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. Stephen Bates
2. P. Harrison
3. W. Cochlan
4. Raphael M. Kudela
5. V. Trainer
6. Anne E. Thessen
7. H. Hégaret
8. A. Lelong

In Environmental Chemistry

1. W. Cochlan
2. Raphael M. Kudela
3. P. Glibert
4. V. Trainer
5. Stephen Bates
6. C. Gobler
7. J. Burkholder
8. D. Anderson

In Oceanography

1. Raphael M. Kudela
2. P. Glibert
3. J. Burkholder
4. W. Cochlan
5. C. Gobler
6. V. Trainer
7. Stephen Bates
8. T. Smayda

Citations in the corpus

• Pseudo-nitzschia physiological ecology, phylogeny, toxicity, monitoring and impacts on ecosystem health (2012, background): “Strains of this species have been shown to produce low levels of DA only in New Zealand (Rhodes et al., 1998), Monterey Bay, California, USA (Wells et al., 2005) and Chesapeake Bay, Maryland, USA (Thessen et al., 2009), but nowhere else.”
• Variability of the phenolic profile in the diatom Phaeodactylum tricornutum growing under copper and iron stress (2013, background): “Wells et al. (2005) reported a synergistic link between the release of the ironcomplexing ligand domoic acid and the limitation by iron and copper in toxigenic diatoms Pseudo-nitzschia spp.”
• The distribution and impacts of harmful algal bloom species in eastern boundary upwelling systems (2010, background): “However, in the Juan de Fuca eddy region at the border of the US and Canada, DA production is not linked to macronutrient limitation, but may be associated with trace metal limitation (Wells et al., 2005; Trainer et al., 2009a).”
• Pseudo-nitzschia (Bacillariophyceae) species, domoic acid and amnesic shellfish poisoning: revisiting previous paradigms (2012, background): “Wells et al. (2005) argue that without sufficient iron and copper, Pseudo-nitzschia will become more toxic by increasing its DA production rate to obtain the low levels of these trace metals via released DA.”
• The role of nutrients in regulation and promotion of harmful algal blooms in upwelling systems (2010, background): “…triggers for increased domoic acid production in culture studies (Bates, 1988; Pan et al., 1996a,b), although Fe and Cu stress have also been implicated in both the laboratory and field (Rue and Bruland, 2001; Maldonado et al., 2002; Ladizinsky, 2003; Wells et al., 2005; Trick et al., 2010).”
• Eutrophication and Harmful Algal Blooms: A Scientific Consensus (2008, background): “For example, laboratory studies have shown that the toxigenic diatoms Pseudo-nitszchia multiseries and P. australis produce increasing amounts of DA as a function of iron or copper limitation (Rue and Bruland, 2001; Maldonado et al., 2002; Wells et al., 2005).”
• Harmful algal blooms along the North American west coast region: History, trends, causes, and impacts (2012, background): “, 2002) or through the stimulation of a Cu-mediated high affinity transport system (Wells et al., 2005).”
• The Ecology of Harmful Diatoms (2006, background): “Both laboratory and field evidence indicate that dissolved DA enhances the rate of Fe uptake (Maldonado et al. 2002; Wells et al. 2005 ).”
• Interactions between Diatoms and Bacteria (2012, background): “DA has been hypothesized to play a role in acquisition of both metals (150), and production of DA appears to increase when Pseudo-nitzschia cells are Fe limited or Cu stressed (with a low or high copper concentration) (114, 184).”
• Production and Toxicity of the Marine Biotoxin Domoic Acid and Its Effects on Wildlife: A Review (2008, background): “Thus, the currently proposed functional role of DA is that it serves to chelate both extracellular Fe and copper (Cu), the latter of which is necessary for the function of high affinity Fe transporters that support growth under Fe-limiting conditions (Wells et al. 2005).”
• Harmful algal blooms: How strong is the evidence that nutrient ratios and forms influence their occurrence? (2012, background): “Wells et al. (2005) reported a link between domoic acid, iron and copper, suggesting that a complex suite of factors influence DA production.”
• Harmful algal blooms and climate change: Learning from the past and present to forecast the future (2015, background): “These changes will increase the selective pressures for low-light adapted species, and changes in UVR may diminish metal (e.g., Fe) availability (e.g., Roy and Wells, 2011), potentially decreasing the toxicity of Pseudo-nitzschia spp. (Maldonado et al., 2002; Wells et al., 2005).”
• Harmful algal blooms and eutrophication: Examining linkages from selected coastal regions of the United States (2008, background): “Limitation by Fe directly modulates Si:N ratios in diatoms, as DA may serve as an Fe-acquisition mechanism (Rue and Bruland, 2001; Wells et al., 2005).”